Circulatory collapse adverse event reports that record this term

Kind of term: MedDRA preferred term
Plain meaning: collapse of the circulation

What a report is

A report is not proof that the drug was the cause of the event.

FDA says:

Adverse event reports submitted to FDA do not undergo extensive validation or verification. Therefore, a causal relationship cannot be established between product and reactions listed in a report. While a suspected relationship may exist, it is not medically validated and should not be the sole source of information for clinical decision making or other assumptions about the safety or efficacy of a product. Additionally, it is important to remember that adverse event reports represent a small percentage of total usage numbers of a product. Common products may have a higher number of adverse events due to the higher total number of people using the product.
Source: openFDA, Drug Adverse Event Overview, section "Responsible use of the data". The site read the page on 2 Oct 2026. The data have the reports that FDA received through 30 Jun 2026.

FDA also says:

There is no certainty that the reported event (adverse event or medication error) was actually due to the product. FDA does not require that a causal relationship between a product and event be proven, and reports do not always contain enough detail to properly evaluate an event. The information in these reports has not been scientifically or otherwise verified as to a cause and effect relationship and cannot be used to estimate the incidence of these events.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated.
Source: openFDA, Response of the drug event API (meta.disclaimer). The site read the page on 2 Oct 2026.

Not medical advice. This site counts what was reported to FDA. Questions about a medicine or device belong with a pharmacist or clinician.

Reports on file

From January 2004 to June 2026, FDA received 16,747 adverse event reports that record the MedDRA preferred term Circulatory collapse. In plain words, the term means: collapse of the circulation. The person who codes a report selects the term that agrees best with the description of the reporter.

FDA received 723 reports in the 12 months to June 2026 and 612 in the 12 months before. FDA releases FAERS data every quarter, so the newest months are not complete. They grow in later releases.

By reports in the 12 months to June 2026, this term was number 779 of 1,436 reaction terms with a page. Of the 1,332,454 drug reports that FDA received in the 12 months to June 2026, 723 (0.1%) record this term. Reports for male patients were 43.3% of the reports that record this term and 34.6% of all drug reports.

The number of people who use the product is not in the data. A count is not a rate.

MedDRA

The Medical Dictionary for Regulatory Activities. The person who codes a report selects the preferred term that agrees best with the description of the reporter. FDA does not publish the description.

Plain meaning

Collapse of the circulation. The words are from the fixed dictionary of this site. They add nothing to a report.

Data version

openFDA FAERS release of 29 Oct 2026. Reports received through 30 Jun 2026.

Drugs in these reports

The table has the 121 drug pages with 50 or more reports that record this term. The rows are in order of name. A drug page with fewer reports for this term is not in the table. The counts are the counts that the site keeps for each reaction term, and a count can be lower than the count of FDA.

FDA says:

Additionally, it is important to remember that adverse event reports represent a small percentage of total usage numbers of a product. Common products may have a higher number of adverse events due to the higher total number of people using the product.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

Importantly, the AEMS data by themselves are not an indicator of the safety profile of the drug or biologic.
Source: FDA, FDA Adverse Event Monitoring System (AEMS) Public Dashboard. Content current as of 11 Mar 2026. The site read the page on 2 Oct 2026.

Drugs that the reports with the term Circulatory collapse name as a suspect product, in order of name
Drug	Class	Reports with this term
Abilify	Atypical antipsychotic	64
Acetaminophen		106
Acetylsalicylic Acid		78
Aclasta		76
Alcohol		61
Alprazolam	Benzodiazepine	84
Amitriptyline		88
Amlodipine	Calcium channel blocker	419
Amoxicillin	Penicillin-class antibacterial	63
Apixaban	Factor Xa inhibitor	85
Aspirin	Nonsteroidal anti-inflammatory drug	181
Atenolol	beta-Adrenergic blocker	148
Atorvastatin		97
Bevacizumab	Vascular endothelial growth factor inhibitor	80
Bisoprolol	beta-Adrenergic blocker	224
Bupropion	Aminoketone	68
Bupropion hydrochloride	Aminoketone	51
Capecitabine	Nucleoside metabolic inhibitor	88
Carboplatin	Platinum-based drug	180
Ciprofloxacin	Fluoroquinolone antibacterial	120
Cisplatin	Platinum-based drug	102
Citalopram	Serotonin reuptake inhibitor	117
Citalopram hydrobromide	Serotonin reuptake inhibitor	63
Clarithromycin	Macrolide antimicrobial	56
Clopidogrel	P2Y12 platelet inhibitor	172
Clozapine	Atypical antipsychotic	185
Clozaril	Atypical antipsychotic	300
Copaxone		60
Cyclophosphamide	Alkylating drug	164
Cyclosporine	Calcineurin inhibitor immunosuppressant	54
Cytarabine	Nucleoside metabolic inhibitor	56
Dexamethasone	Corticosteroid	221
Diazepam	Benzodiazepine	131
Diclofenac	Nonsteroidal anti-inflammatory drug	101
Diclofenac sodium	Nonsteroidal anti-inflammatory drug	64
Digoxin	Cardiac glycoside	62
Diltiazem		50
Diprivan	General anesthetic	83
Docetaxel	Microtubule inhibitor	119
Donepezil		79
Doxorubicin	Anthracycline topoisomerase inhibitor	53
Eliquis	Factor Xa inhibitor	93
Entresto	Angiotensin 2 receptor blocker	88
Epinephrine	Catecholamine	86
Escitalopram	Serotonin reuptake inhibitor	64
Etoposide	Topoisomerase inhibitor	80
Fentanyl	Opioid agonist	184
Ferinject		86
Fluorouracil	Nucleoside metabolic inhibitor	121
Furosemide	Loop diuretic	195
Gabapentin	Anti-epileptic agent	66
Humira		138
Hydrochlorothiazide	Thiazide diuretic	92
Ibuprofen	Nonsteroidal anti-inflammatory drug	237
Lamotrigine	Anti-epileptic agent	61
Lansoprazole	Proton pump inhibitor	63
Leucovorin		53
Levetiracetam		131
Levofloxacin	Fluoroquinolone antibacterial	57
Levothyroxine sodium	l-Thyroxine	69
Lidocaine	Amide local anesthetic	107
Lisinopril	Angiotensin converting enzyme inhibitor	63
Lorazepam	Benzodiazepine	78
Lyrica		75
Meropenem	Penem antibacterial	54
Metformin	Biguanide	292
Metformin hcl	Biguanide	52
Metformin hydrochloride	Biguanide	71
Methotrexate	Folate analog metabolic inhibitor	163
Methylprednisolone	Corticosteroid	89
Metoprolol	beta-Adrenergic blocker	197
Midazolam	Benzodiazepine	104
Mirena	Progestin	50
Mirtazapine		154
Morphine	Opioid agonist	60
Mycophenolate mofetil	Antimetabolite immunosuppressant	73
Norepinephrine	Catecholamine	51
Olanzapine	Atypical antipsychotic	122
Omeprazole	Proton pump inhibitor	170
Oxaliplatin	Platinum-based drug	181
Paclitaxel	Microtubule inhibitor	112
Pantoprazole	Proton pump inhibitor	65
Paracetamol		104
Piperacillin and tazobactam	Penicillin-class antibacterial	56
Potassium chloride	Osmotic laxative	62
Pradaxa	Direct thrombin inhibitor	71
Prednisolone	Corticosteroid	245
Prednisone	Corticosteroid	96
Pregabalin		96
Propofol	General anesthetic	304
Propranolol	beta-Adrenergic blocker	120
Quetiapine	Atypical antipsychotic	244
Quetiapine fumarate	Atypical antipsychotic	51
Ramipril	Angiotensin converting enzyme inhibitor	195
Ranitidine	Histamine-2 receptor antagonist	53
Revlimid	Thalidomide analog	72
Risperidone	Atypical antipsychotic	67
Rituximab	CD20-directed cytolytic antibody	80
Rivaroxaban	Factor Xa inhibitor	62
Rocuronium	Nondepolarizing neuromuscular blocker	67
Rocuronium bromide	Nondepolarizing neuromuscular blocker	95
Seroquel	Atypical antipsychotic	61
Sertraline	Serotonin reuptake inhibitor	147
Simvastatin	HMG-CoA reductase inhibitor	100
Sodium chloride	Osmotic laxative	51
Spironolactone	Aldosterone antagonist	59
Sufentanil		50
Tacrolimus	Calcineurin inhibitor immunosuppressant	96
Tamsulosin		79
Tracleer	Endothelin receptor antagonist	55
Tramadol		138
Tramadol hydrochloride	Opioid agonist	72
Trastuzumab	HER2/neu receptor antagonist	51
Valsartan	Angiotensin 2 receptor blocker	73
Vancomycin	Glycopeptide antibacterial	87
Venlafaxine	Serotonin and norepinephrine reuptake inhibitor	107
Verapamil		60
Vincristine		75
Warfarin	Vitamin K antagonist	64
Xarelto	Factor Xa inhibitor	142
Xeloda	Nucleoside metabolic inhibitor	61

The page of each drug has the count of each reaction term in its reaction lookup.

Drug classes in these reports

The table has the 46 pharmacologic classes with 100 or more reports that record this term. The rows are in order of name.

FDA says:

Additionally, it is important to remember that adverse event reports represent a small percentage of total usage numbers of a product. Common products may have a higher number of adverse events due to the higher total number of people using the product.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

Importantly, the AEMS data by themselves are not an indicator of the safety profile of the drug or biologic.
Source: FDA, FDA Adverse Event Monitoring System (AEMS) Public Dashboard. Content current as of 11 Mar 2026. The site read the page on 2 Oct 2026.

Pharmacologic classes of the drugs that the reports with the term Circulatory collapse name, in order of name
Class	Reports with this term
Aldosterone antagonist	121
Alkylating drug	209
alpha-Adrenergic blocker	128
Amide local anesthetic	205
Aminoketone	129
Angiotensin 2 receptor blocker	357
Angiotensin converting enzyme inhibitor	328
Anti-epileptic agent	243
Antimetabolite immunosuppressant	100
Atypical antipsychotic	1,239
Benzodiazepine	544
beta-Adrenergic blocker	857
Biguanide	439
Calcineurin inhibitor immunosuppressant	187
Calcium channel blocker	459
Catecholamine	150
CD20-directed cytolytic antibody	129
Cephalosporin antibacterial	144
Corticosteroid	773
Dihydropyridine calcium channel blocker	106
Endothelin receptor antagonist	106
Factor Xa inhibitor	407
Fluoroquinolone antibacterial	200
Folate analog metabolic inhibitor	235
General anesthetic	443
Glycopeptide antibacterial	104
HER2/neu receptor antagonist	139
HMG-CoA reductase inhibitor	213
Kinase inhibitor	295
Loop diuretic	270
Microtubule inhibitor	249
Nondepolarizing neuromuscular blocker	189
Nonsteroidal anti-inflammatory drug	699
Nucleoside metabolic inhibitor	426
Opioid agonist	595
Osmotic laxative	190
P2Y12 platelet inhibitor	259
Penicillin-class antibacterial	162
Platinum-based drug	463
Programmed death Receptor-1 blocking antibody	160
Proton pump inhibitor	380
Serotonin and norepinephrine reuptake inhibitor	240
Serotonin reuptake inhibitor	572
Thalidomide analog	107
Tumor necrosis factor blocker	159
Vascular endothelial growth factor inhibitor	171

A class with many reports in all has many reports for almost every term.

Reports by month

Reports that record Circulatory collapse, by month, five years to June 2026

FDA releases FAERS data every quarter, so the newest months are not complete. They grow in later releases.

Patients in these reports

Age of the patient in the reports that record Circulatory collapse
Age	Reports	Share
Under 2	195	1.2%
2 to 11	260	1.6%
12 to 17	426	2.5%
18 to 44	2,795	16.7%
45 to 64	3,827	22.9%
65 to 74	2,444	14.6%
75 and over	2,842	17%
Age not given	3,958	23.6%

Sex of the patient in the reports that record Circulatory collapse
Sex	Reports	Share
Female	8,166	48.8%
Male	7,251	43.3%
Unknown or not given	1,330	7.9%

Age and sex are as the report gives them. 15.7% of these reports give the United States as the country.

Terms near this one

These are the next terms in the A to Z list. The links are for navigation.

Official pages

MedWatch Online Voluntary Reporting FormThe online form of FDA for a voluntary report.
MedWatch: The FDA Safety Information and Adverse Event Reporting ProgramThe page of the FDA program that receives reports about drugs and devices.
FDA Adverse Event Monitoring System (AEMS) Public DashboardThe public dashboard of FDA for adverse event reports on drugs and biologics.

The site checked these addresses on 2 Oct 2026. The links open in a new tab.

Cite this page

Reported Reactions. Circulatory collapse: adverse event reports that record this term. https://reportedreactions.com/reaction/circulatory-collapse/ Source: U.S. Food and Drug Administration, openFDA Drug Adverse Event (FAERS) files, release of 29 Oct 2026. Reports received through 30 Jun 2026.

Where the data come from

The counts come from the openFDA Drug Adverse Event (FAERS) bulk files, release of 29 Oct 2026. The files have the reports that FDA received through 30 Jun 2026. A drug name is the name on the report. The site matches it to a brand name or a generic name of the National Drug Code Directory of 2 Nov 2026. A class is the pharmacologic class (EPC) of the FDA label.

The count has the reports with each spelling of one MedDRA preferred term. The site does not publish a report narrative, a lot number, a detail of a patient or the identity of a reporter. The record of FDA is the authority. See how the site counts reports, the data sources and the corrections page.

Questions

What does Circulatory collapse mean in an adverse event report?

In plain words: collapse of the circulation. It is a MedDRA preferred term. FDA codes the description of a reporter with the MedDRA dictionary. The openFDA files do not have the description itself, and this site does not show it.

Does a drug in the table mean that the drug was responsible for this reaction?

No. FDA says:

No individual drug is connected to any individual reaction.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

When a report lists multiple drugs and multiple reactions, there is no way to conclude from the data therein that a given drug is responsible for a given reaction.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

What does this page tell a person who has this symptom?

This page gives counts of reports. It cannot assess a person. A pharmacist or a clinician can assess a person.

If this is a medical emergency, please call 911.
Source: FDA, MedWatch Online Voluntary Reporting Form. The site read the page on 2 Oct 2026.

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