MedDRA preferred term · reduced movement of a joint
Joint range of motion decreased: adverse event reports recording this term
13,173 reports to FDA record it, 2004–2026; 0.1% of the database.
- 13,173
- reports recording the term
- 0.1% of all reports
- 1,021
- reports, 12 months to June 2026
- 1,505 in the 12 months before
- 78.3%
- marked serious by the reporter
- 57.4% across all reports
- 20%
- record death among outcomes, as reported
- 9.1% across all reports
13,173 reports in FDA's adverse event database record the MedDRA term "Joint range of motion decreased" (in plain words, reduced movement of a joint): 0.1% of all reports received between January 2004 and June 2026. Coders pick the term that best matches the reporter's description.
1,021 reports recorded it in the 12 months to June 2026, down 32% from 1,505 in the 12 months before. FDA releases FAERS data quarterly, so the newest months are incomplete and grow in later releases. Of reports recording this term, 78.3% are marked serious, 20% include death among the outcomes and 36.8% include hospitalisation, as reported.
The drugs listed most often as suspect products in those reports are Humira, Enbrel and Methotrexate. That order mostly follows how many reports each drug has overall; the table also gives the term's share within each drug's own reports. FDA states that "a causal relationship cannot be established between product and reactions listed in a report" and that for any given report "there is no certainty that a suspected drug caused the event."
Reports by month, five years
FDA releases FAERS data quarterly, so the newest months are incomplete and grow in later releases.
Drugs listed as suspect products in these reports
| Drug | Class | Reports with this term | Share of the drug's own reports |
|---|---|---|---|
| Humira | — | 4,225 | 0.7% |
| Enbrel | Tumor necrosis factor blocker | 3,271 | 0.6% |
| Methotrexate | Folate analog metabolic inhibitor | 2,882 | 1.4% |
| Orencia | Selective T cell costimulation modulator | 2,382 | 2.2% |
| Rituximab | CD20-directed cytolytic antibody | 2,381 | 1.5% |
| Xeljanz | Janus kinase inhibitor | 2,333 | 1.5% |
| Actemra | Interleukin-6 receptor antagonist | 2,247 | 2.8% |
| Prednisone | Corticosteroid | 2,191 | 1.2% |
| Sulfasalazine | Aminosalicylate | 2,128 | 5.2% |
| Leflunomide | Antirheumatic agent | 2,119 | 5.7% |
| Cosentyx | Interleukin-17A antagonist | 1,967 | 1.3% |
| Diclofenac sodium | Nonsteroidal anti-inflammatory drug | 1,958 | 3.8% |
| Arava | Antirheumatic agent | 1,891 | 5.5% |
| Folic acid | Vitamin B12 | 1,859 | 7.7% |
| Cimzia | Tumor necrosis factor blocker | 1,804 | 2.1% |
| Adalimumab | Tumor necrosis factor blocker | 1,802 | 4.6% |
| Desoximetasone | Corticosteroid | 1,776 | 14.5% |
| Erelzi | — | 1,730 | 13% |
| Simponi | Tumor necrosis factor blocker | 1,668 | 2.4% |
| Acetaminophen | Nonsteroidal anti-inflammatory drug | 1,657 | 1.9% |
| Fosamax | Bisphosphonate | 1,645 | 4.7% |
| Phthalylsulfathiazole | — | 1,612 | 16% |
| Hydroxychloroquine | Antimalarial | 1,590 | 3.9% |
| Infliximab | Tumor necrosis factor blocker | 1,548 | 2.9% |
| Remicade | Tumor necrosis factor blocker | 1,440 | 0.9% |
Drugs with a page on this site, ordered by the number of their reports recording this term. The last column is the term's share within that drug's own reports, against 0.1% across the whole database. FDA states that adverse event reports "represent a small percentage of total usage numbers of a product", that "common products may have a higher number of adverse events due to the higher total number of people using the product", and that the data "by themselves are not an indicator of the safety profile of the drug or biologic."
By pharmacologic class
| Class | Reports with this term | Share of class reports | Median drug in class |
|---|---|---|---|
| Tumor necrosis factor blocker | 13,659 | 1.3% | 0.9% |
| Corticosteroid | 11,641 | 1.4% | 0% |
| Nonsteroidal anti-inflammatory drug | 11,198 | 2% | 0% |
| Opioid agonist | 4,356 | 0.5% | 0% |
| Janus kinase inhibitor | 4,027 | 1.2% | 0% |
| Antirheumatic agent | 4,010 | 5.6% | 5.6% |
| Interleukin-6 receptor antagonist | 3,960 | 3% | 3% |
| Histamine-1 receptor antagonist | 3,830 | 2.8% | 0% |
| Antimalarial | 3,585 | 3.9% | 0% |
| Folate analog metabolic inhibitor | 3,476 | 1.1% | 0% |
Classes ordered by count. Class shares follow the class's overall report volume as much as anything else.
Patients in these reports
Patient age
Patient sex
Grey bar: all 20,646,523 reports in the database. 52.1% of these reports give the United States as the country.
Questions about "Joint range of motion decreased"
What does "Joint range of motion decreased" mean in an adverse event report?
In plain language: reduced movement of a joint. It is a MedDRA preferred term, the dictionary FDA uses to code what a reporter described. The report's own description is not published by openFDA and is not shown here.
How many reports record joint range of motion decreased?
13,173 reports through June 2026 (0.1% of all reports), 1,021 of them in the latest 12 months.
Which drugs appear most often in these reports?
Humira (4,225), Enbrel (3,271), Methotrexate (2,882), Orencia (2,382) and Rituximab (2,381). Drugs with many reports overall lead almost every term's list. FDA states that adverse event reports "represent a small percentage of total usage numbers of a product", that "common products may have a higher number of adverse events due to the higher total number of people using the product", and that the data "by themselves are not an indicator of the safety profile of the drug or biologic."
Does a drug appearing here mean it was responsible for this reaction?
No. FDA states that "a causal relationship cannot be established between product and reactions listed in a report" and that for any given report "there is no certainty that a suspected drug caused the event."
I have this symptom. What should I do?
This site cannot assess anyone. A pharmacist or clinician can; for an emergency, call the local emergency number. Nothing on this page is medical advice.
Where this comes from. Counts are built from the openFDA Drug Adverse Event (FAERS) bulk export released 28 Sep 2026, which holds reports FDA received through 30 Jun 2026. Drug names are as reported, resolved to the brand or generic name on the FDA label where openFDA's harmonisation matched them; classes are the pharmacologic class (EPC) from the label and the National Drug Code Directory of 17 Sep 2026. Terms are pooled across spelling and capitalisation variants of one MedDRA preferred term. No report narrative, lot number, patient detail or reporter identity is published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.
Drug data (FAERS) through 30 Jun 2026; device data (MAUDE) through 31 Aug 2026. Not medical advice.