MedDRA preferred term

Disseminated intravascular coagulation: adverse event reports recording this term

13,822 reports to FDA record it, 2004–2026; 0.1% of the database.

Read first · FDA's statement on these data

Adverse event reports submitted to FDA do not undergo extensive validation or verification. Therefore, a causal relationship cannot be established between product and reactions listed in a report. While a suspected relationship may exist, it is not medically validated and should not be the sole source of information for clinical decision making or other assumptions about the safety or efficacy of a product. Additionally, it is important to remember that adverse event reports represent a small percentage of total usage numbers of a product. Common products may have a higher number of adverse events due to the higher total number of people using the product. openFDA, FDA

FDA adds: "There is no certainty that the reported event (adverse event or medication error) was actually due to the product. FDA does not require that a causal relationship between a product and event be proven, and reports do not always contain enough detail to properly evaluate an event." The information in these reports "cannot be used to estimate the incidence of these events."

Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated.

Not medical advice. This site counts what was reported to FDA. Questions about a medicine or device belong with a pharmacist or clinician.

13,822
reports recording the term: 0.1% of all reports; 623
reports, 12 months to June 2026: 595 in the 12 months before; 99.5%
marked serious by the reporter: 57.4% across all reports; 54.7%
record death among outcomes, as reported: 9.1% across all reports

"Disseminated intravascular coagulation" is a MedDRA preferred term recorded in 13,822 adverse event reports received by FDA, 0.1% of the database, from January 2004 to June 2026. The term is chosen by whoever codes the report to match what the reporter described.

623 reports recorded it in the 12 months to June 2026, close to the 595 of the 12 months before. FDA releases FAERS data quarterly, so the newest months are incomplete and grow in later releases. Of reports recording this term, 99.5% are marked serious, 54.7% include death among the outcomes and 59.7% include hospitalisation, as reported.

The drugs listed most often as suspect products in those reports are Prednisolone, Methotrexate and Prednisone. That order mostly follows how many reports each drug has overall; the table also gives the term's share within each drug's own reports. FDA states that "a causal relationship cannot be established between product and reactions listed in a report" and that for any given report "there is no certainty that a suspected drug caused the event."

Reports by month, five years

FDA releases FAERS data quarterly, so the newest months are incomplete and grow in later releases.

Drugs listed as suspect products in these reports

Drug	Class	Reports with this term	Share of the drug's own reports
Prednisolone	Corticosteroid	507	0.6%
Methotrexate	Folate analog metabolic inhibitor	459	0.2%
Prednisone	Corticosteroid	382	0.2%
Dexamethasone	Corticosteroid	380	0.3%
Cyclophosphamide	Alkylating drug	379	0.3%
Tacrolimus	Calcineurin inhibitor immunosuppressant	323	0.3%
Methylprednisolone	Corticosteroid	305	0.6%
Etoposide	Topoisomerase inhibitor	300	0.5%
Cytarabine	Nucleoside metabolic inhibitor	275	0.5%
Rituximab	CD20-directed cytolytic antibody	272	0.2%
Mycophenolate mofetil	Antimetabolite immunosuppressant	262	0.3%
Oxaliplatin	Platinum-based drug	257	0.4%
Avastin	Vascular endothelial growth factor inhibitor	243	0.4%
Carboplatin	Platinum-based drug	227	0.2%
Opdivo	Programmed death Receptor-1 blocking antibody	203	0.4%
Keytruda	Programmed death Receptor-1 blocking antibody	202	0.3%
Fluorouracil	Nucleoside metabolic inhibitor	196	0.3%
Vincristine	—	181	0.3%
Cisplatin	Platinum-based drug	175	0.3%
Vincristine sulfate	Vinca alkaloid	170	0.6%
Paclitaxel	Microtubule inhibitor	163	0.2%
Vancomycin	Glycopeptide antibacterial	159	0.5%
Lamotrigine	Anti-epileptic agent	156	0.4%
Cyclosporine	Calcineurin inhibitor immunosuppressant	148	0.4%
Heparin	—	140	1%

Drugs with a page on this site, ordered by the number of their reports recording this term. The last column is the term's share within that drug's own reports, against 0.1% across the whole database. FDA states that adverse event reports "represent a small percentage of total usage numbers of a product", that "common products may have a higher number of adverse events due to the higher total number of people using the product", and that the data "by themselves are not an indicator of the safety profile of the drug or biologic."

By pharmacologic class

Class	Reports with this term	Share of class reports	Median drug in class
Corticosteroid	1,803	0.2%	0%
Nucleoside metabolic inhibitor	1,036	0.3%	0.3%
Kinase inhibitor	816	0.1%	0%
Platinum-based drug	659	0.3%	0.3%
Programmed death Receptor-1 blocking antibody	647	0.3%	0.2%
Calcineurin inhibitor immunosuppressant	637	0.3%	0.1%
Folate analog metabolic inhibitor	586	0.2%	0.1%
Alkylating drug	558	0.2%	0.1%
Nonsteroidal anti-inflammatory drug	479	0.1%	0%
Antimetabolite immunosuppressant	384	0.3%	0.3%

Classes ordered by count. Class shares follow the class's overall report volume as much as anything else.

Patients in these reports

Patient age

Under 22.2%307

2 to 113%421

12 to 172.7%373

18 to 4416.2%2,233

45 to 6422.9%3,171

65 to 7418.8%2,596

75 and over14.7%2,026

Age not given19.5%2,695

Patient sex

Female44.1%6,096

Male47.3%6,531

Not given8.6%1,195

Grey bar: all 20,646,523 reports in the database. 22.2% of these reports give the United States as the country.

Questions about "Disseminated intravascular coagulation"

What does "Disseminated intravascular coagulation" mean in an adverse event report?

It is a MedDRA preferred term, the dictionary FDA uses to code what a reporter described. The report's own description is not published by openFDA and is not shown here.

How many reports record disseminated intravascular coagulation?

13,822 reports through June 2026 (0.1% of all reports), 623 of them in the latest 12 months.

Which drugs appear most often in these reports?

Prednisolone (507), Methotrexate (459), Prednisone (382), Dexamethasone (380) and Cyclophosphamide (379). Drugs with many reports overall lead almost every term's list. FDA states that adverse event reports "represent a small percentage of total usage numbers of a product", that "common products may have a higher number of adverse events due to the higher total number of people using the product", and that the data "by themselves are not an indicator of the safety profile of the drug or biologic."

Does a drug appearing here mean it was responsible for this reaction?

No. FDA states that "a causal relationship cannot be established between product and reactions listed in a report" and that for any given report "there is no certainty that a suspected drug caused the event."

I have this symptom. What should I do?

This site cannot assess anyone. A pharmacist or clinician can; for an emergency, call the local emergency number. Nothing on this page is medical advice.

Where this comes from. Counts are built from the openFDA Drug Adverse Event (FAERS) bulk export released 28 Sep 2026, which holds reports FDA received through 30 Jun 2026. Drug names are as reported, resolved to the brand or generic name on the FDA label where openFDA's harmonisation matched them; classes are the pharmacologic class (EPC) from the label and the National Drug Code Directory of 17 Sep 2026. Terms are pooled across spelling and capitalisation variants of one MedDRA preferred term. No report narrative, lot number, patient detail or reporter identity is published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.

Drug data (FAERS) through 30 Jun 2026; device data (MAUDE) through 31 Aug 2026. Not medical advice.