Cardiac failure acute adverse event reports that record this term

Kind of term: MedDRA preferred term

What a report is

A report is not proof that the drug was the cause of the event.

FDA says:

Adverse event reports submitted to FDA do not undergo extensive validation or verification. Therefore, a causal relationship cannot be established between product and reactions listed in a report. While a suspected relationship may exist, it is not medically validated and should not be the sole source of information for clinical decision making or other assumptions about the safety or efficacy of a product. Additionally, it is important to remember that adverse event reports represent a small percentage of total usage numbers of a product. Common products may have a higher number of adverse events due to the higher total number of people using the product.
Source: openFDA, Drug Adverse Event Overview, section "Responsible use of the data". The site read the page on 2 Oct 2026. The data have the reports that FDA received through 30 Jun 2026.

FDA also says:

There is no certainty that the reported event (adverse event or medication error) was actually due to the product. FDA does not require that a causal relationship between a product and event be proven, and reports do not always contain enough detail to properly evaluate an event. The information in these reports has not been scientifically or otherwise verified as to a cause and effect relationship and cannot be used to estimate the incidence of these events.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated.
Source: openFDA, Response of the drug event API (meta.disclaimer). The site read the page on 2 Oct 2026.

Not medical advice. This site counts what was reported to FDA. Questions about a medicine or device belong with a pharmacist or clinician.

Reports on file

From January 2004 to June 2026, FDA received 6,543 adverse event reports that record the MedDRA preferred term Cardiac failure acute. The person who codes a report selects the term that agrees best with the description of the reporter.

FDA received 462 reports in the 12 months to June 2026 and 507 in the 12 months before. FDA releases FAERS data every quarter, so the newest months are not complete. They grow in later releases.

By reports in the 12 months to June 2026, this term was number 1,027 of 1,436 reaction terms with a page. Of the 1,332,454 drug reports that FDA received in the 12 months to June 2026, 462 (under 0.1%) record this term. Reports for patients 75 and over were 23.5% of the reports that record this term and 9.5% of all drug reports.

The number of people who use the product is not in the data. A count is not a rate.

MedDRA

The Medical Dictionary for Regulatory Activities. The person who codes a report selects the preferred term that agrees best with the description of the reporter. FDA does not publish the description.

Data version

openFDA FAERS release of 29 Oct 2026. Reports received through 30 Jun 2026.

Drugs in these reports

The table has the 93 drug pages with 25 or more reports that record this term. The rows are in order of name. A drug page with fewer reports for this term is not in the table. The counts are the counts that the site keeps for each reaction term, and a count can be lower than the count of FDA.

FDA says:

Additionally, it is important to remember that adverse event reports represent a small percentage of total usage numbers of a product. Common products may have a higher number of adverse events due to the higher total number of people using the product.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

Importantly, the AEMS data by themselves are not an indicator of the safety profile of the drug or biologic.
Source: FDA, FDA Adverse Event Monitoring System (AEMS) Public Dashboard. Content current as of 11 Mar 2026. The site read the page on 2 Oct 2026.

Drugs that the reports with the term Cardiac failure acute name as a suspect product, in order of name
Drug	Class	Reports with this term
Adempas	Soluble guanylate cyclase stimulator	38
Aggrastat	Platelet aggregation inhibitor	116
Allopurinol	Xanthine oxidase inhibitor	26
Ambrisentan	Endothelin receptor antagonist	57
Amiodarone		66
Amlodipine	Calcium channel blocker	43
Apixaban	Factor Xa inhibitor	37
Aspirin	Nonsteroidal anti-inflammatory drug	66
Atorvastatin		42
Avandia		25
Avastin	Vascular endothelial growth factor inhibitor	25
Bevacizumab	Vascular endothelial growth factor inhibitor	42
Bisoprolol	beta-Adrenergic blocker	76
Bortezomib	Proteasome inhibitor	32
Bumetanide	Loop diuretic	33
Capecitabine	Nucleoside metabolic inhibitor	42
Carboplatin	Platinum-based drug	81
Carfilzomib	Proteasome inhibitor	40
Carvedilol	alpha-Adrenergic blocker	39
Ciprofloxacin	Fluoroquinolone antibacterial	29
Cisplatin	Platinum-based drug	47
Clopidogrel	P2Y12 platelet inhibitor	26
Clozapine	Atypical antipsychotic	27
Cocaine		44
Cyclophosphamide	Alkylating drug	147
Cyclosporine	Calcineurin inhibitor immunosuppressant	37
Cytarabine	Nucleoside metabolic inhibitor	65
Dapagliflozin	Sodium-Glucose cotransporter 2 inhibitor	47
Dexamethasone	Corticosteroid	124
Diazepam	Benzodiazepine	25
Digoxin	Cardiac glycoside	33
Diovan	Angiotensin 2 receptor blocker	37
Docetaxel	Microtubule inhibitor	51
Doxorubicin	Anthracycline topoisomerase inhibitor	106
Doxorubicin hydrochloride	Anthracycline topoisomerase inhibitor	47
Edoxaban tosylate	Factor Xa inhibitor	39
Eliquis	Factor Xa inhibitor	64
Entresto	Angiotensin 2 receptor blocker	215
Epirubicin		30
Eplerenone	Aldosterone antagonist	35
Etoposide	Topoisomerase inhibitor	38
Fluorouracil	Nucleoside metabolic inhibitor	78
Furosemide	Loop diuretic	126
Gemcitabine	Nucleoside metabolic inhibitor	38
Glivec		34
Humira		51
Hydroxychloroquine	Antimalarial	29
Ibuprofen	Nonsteroidal anti-inflammatory drug	25
Jardiance	Sodium-Glucose cotransporter 2 inhibitor	27
Keytruda	Programmed death Receptor-1 blocking antibody	78
Lasix	Loop diuretic	35
Lenalidomide	Thalidomide analog	32
Linezolid	Oxazolidinone antibacterial	27
Lisinopril	Angiotensin converting enzyme inhibitor	27
Melphalan	Alkylating drug	25
Metformin	Biguanide	32
Methadone	Opioid agonist	27
Methotrexate	Folate analog metabolic inhibitor	94
Methylprednisolone	Corticosteroid	68
Metoprolol	beta-Adrenergic blocker	53
Metoprolol succinate	beta-Adrenergic blocker	26
Mycophenolate mofetil	Antimetabolite immunosuppressant	83
Nivolumab	Programmed death Receptor-1 blocking antibody	39
Omeprazole	Proton pump inhibitor	25
Opdivo	Programmed death Receptor-1 blocking antibody	26
Opsumit	Endothelin receptor antagonist	102
Oxaliplatin	Platinum-based drug	45
Paclitaxel	Microtubule inhibitor	72
Pembrolizumab	Programmed death Receptor-1 blocking antibody	27
Pradaxa	Direct thrombin inhibitor	42
Prednisolone	Corticosteroid	57
Prednisone	Corticosteroid	126
Remodulin	Prostacycline vasodilator	80
Revlimid	Thalidomide analog	73
Rituximab	CD20-directed cytolytic antibody	85
Sacubitril valsartan		26
Sildenafil	Phosphodiesterase 5 inhibitor	27
Simvastatin	HMG-CoA reductase inhibitor	55
Spironolactone	Aldosterone antagonist	53
Tacrolimus	Calcineurin inhibitor immunosuppressant	87
Tagrisso	Kinase inhibitor	29
Torsemide	Loop diuretic	41
Tracleer	Endothelin receptor antagonist	57
Tramadol		31
Trastuzumab	HER2/neu receptor antagonist	40
Uptravi	Prostacyclin receptor agonist	49
Valsartan	Angiotensin 2 receptor blocker	36
Velcade	Proteasome inhibitor	43
Venetoclax	BCL-2 inhibitor	26
Venlafaxine	Serotonin and norepinephrine reuptake inhibitor	42
Vincristine		56
Vyndamax		27
Xarelto	Factor Xa inhibitor	67

The page of each drug has the count of each reaction term in its reaction lookup.

Drug classes in these reports

The table has the 38 pharmacologic classes with 50 or more reports that record this term. The rows are in order of name.

FDA says:

Additionally, it is important to remember that adverse event reports represent a small percentage of total usage numbers of a product. Common products may have a higher number of adverse events due to the higher total number of people using the product.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

Importantly, the AEMS data by themselves are not an indicator of the safety profile of the drug or biologic.
Source: FDA, FDA Adverse Event Monitoring System (AEMS) Public Dashboard. Content current as of 11 Mar 2026. The site read the page on 2 Oct 2026.

Pharmacologic classes of the drugs that the reports with the term Cardiac failure acute name, in order of name
Class	Reports with this term
Aldosterone antagonist	98
Alkylating drug	202
alpha-Adrenergic blocker	64
Angiotensin 2 receptor blocker	314
Angiotensin converting enzyme inhibitor	79
Anthracycline topoisomerase inhibitor	176
Antimetabolite immunosuppressant	140
Atypical antipsychotic	138
Benzodiazepine	88
beta-Adrenergic blocker	201
Calcineurin inhibitor immunosuppressant	144
CD20-directed cytolytic antibody	93
Corticosteroid	407
Endothelin receptor antagonist	240
Factor Xa inhibitor	216
Folate analog metabolic inhibitor	124
HER2/neu receptor antagonist	83
HMG-CoA reductase inhibitor	108
Kinase inhibitor	246
Loop diuretic	245
Microtubule inhibitor	133
Nonsteroidal anti-inflammatory drug	154
Nucleoside metabolic inhibitor	282
Opioid agonist	91
P2Y12 platelet inhibitor	78
Phosphodiesterase 5 inhibitor	63
Platelet aggregation inhibitor	117
Platinum-based drug	173
Programmed death Receptor-1 blocking antibody	191
Prostacycline vasodilator	156
Proteasome inhibitor	143
Proton pump inhibitor	98
Serotonin and norepinephrine reuptake inhibitor	62
Serotonin reuptake inhibitor	62
Sodium-Glucose cotransporter 2 inhibitor	90
Thalidomide analog	119
Tumor necrosis factor blocker	83
Vascular endothelial growth factor inhibitor	69

A class with many reports in all has many reports for almost every term.

Reports by month

Reports that record Cardiac failure acute, by month, five years to June 2026

FDA releases FAERS data every quarter, so the newest months are not complete. They grow in later releases.

Patients in these reports

Age of the patient in the reports that record Cardiac failure acute
Age	Reports	Share
Under 2	26	0.4%
2 to 11	62	0.9%
12 to 17	67	1%
18 to 44	738	11.3%
45 to 64	1,428	21.8%
65 to 74	1,285	19.6%
75 and over	1,538	23.5%
Age not given	1,399	21.4%

Sex of the patient in the reports that record Cardiac failure acute
Sex	Reports	Share
Female	2,789	42.6%
Male	3,003	45.9%
Unknown or not given	751	11.5%

Age and sex are as the report gives them. 26.8% of these reports give the United States as the country.

Terms near this one

These are the next terms in the A to Z list. The links are for navigation.

Official pages

MedWatch Online Voluntary Reporting FormThe online form of FDA for a voluntary report.
MedWatch: The FDA Safety Information and Adverse Event Reporting ProgramThe page of the FDA program that receives reports about drugs and devices.
FDA Adverse Event Monitoring System (AEMS) Public DashboardThe public dashboard of FDA for adverse event reports on drugs and biologics.

The site checked these addresses on 2 Oct 2026. The links open in a new tab.

Cite this page

Reported Reactions. Cardiac failure acute: adverse event reports that record this term. https://reportedreactions.com/reaction/cardiac-failure-acute/ Source: U.S. Food and Drug Administration, openFDA Drug Adverse Event (FAERS) files, release of 29 Oct 2026. Reports received through 30 Jun 2026.

Where the data come from

The counts come from the openFDA Drug Adverse Event (FAERS) bulk files, release of 29 Oct 2026. The files have the reports that FDA received through 30 Jun 2026. A drug name is the name on the report. The site matches it to a brand name or a generic name of the National Drug Code Directory of 2 Nov 2026. A class is the pharmacologic class (EPC) of the FDA label.

The count has the reports with each spelling of one MedDRA preferred term. The site does not publish a report narrative, a lot number, a detail of a patient or the identity of a reporter. The record of FDA is the authority. See how the site counts reports, the data sources and the corrections page.

Questions

What does Cardiac failure acute mean in an adverse event report?

It is a MedDRA preferred term. FDA codes the description of a reporter with the MedDRA dictionary. The openFDA files do not have the description itself, and this site does not show it.

Does a drug in the table mean that the drug was responsible for this reaction?

No. FDA says:

No individual drug is connected to any individual reaction.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

When a report lists multiple drugs and multiple reactions, there is no way to conclude from the data therein that a given drug is responsible for a given reaction.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

What does this page tell a person who has this symptom?

This page gives counts of reports. It cannot assess a person. A pharmacist or a clinician can assess a person.

If this is a medical emergency, please call 911.
Source: FDA, MedWatch Online Voluntary Reporting Form. The site read the page on 2 Oct 2026.

To the top of the page