MedDRA preferred term

Small intestinal obstruction: adverse event reports recording this term

12,083 reports to FDA record it, 2004–2026; 0.1% of the database.

Read first · FDA's statement on these data

Adverse event reports submitted to FDA do not undergo extensive validation or verification. Therefore, a causal relationship cannot be established between product and reactions listed in a report. While a suspected relationship may exist, it is not medically validated and should not be the sole source of information for clinical decision making or other assumptions about the safety or efficacy of a product. Additionally, it is important to remember that adverse event reports represent a small percentage of total usage numbers of a product. Common products may have a higher number of adverse events due to the higher total number of people using the product. openFDA, FDA

FDA adds: "There is no certainty that the reported event (adverse event or medication error) was actually due to the product. FDA does not require that a causal relationship between a product and event be proven, and reports do not always contain enough detail to properly evaluate an event." The information in these reports "cannot be used to estimate the incidence of these events."

Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated.

Not medical advice. This site counts what was reported to FDA. Questions about a medicine or device belong with a pharmacist or clinician.

12,083
reports recording the term: 0.1% of all reports; 814
reports, 12 months to June 2026: 774 in the 12 months before; 98.9%
marked serious by the reporter: 57.4% across all reports; 9.8%
record death among outcomes, as reported: 9.1% across all reports

12,083 reports in FDA's adverse event database record the MedDRA term "Small intestinal obstruction": 0.1% of all reports received between January 2004 and June 2026. Coders pick the term that best matches the reporter's description.

814 reports recorded it in the 12 months to June 2026, close to the 774 of the 12 months before. FDA releases FAERS data quarterly, so the newest months are incomplete and grow in later releases. Of reports recording this term, 98.9% are marked serious, 9.8% include death among the outcomes and 81.1% include hospitalisation, as reported.

The drugs listed most often as suspect products in those reports are Humira, Bevacizumab and Skyrizi. That order mostly follows how many reports each drug has overall; the table also gives the term's share within each drug's own reports. FDA states that "a causal relationship cannot be established between product and reactions listed in a report" and that for any given report "there is no certainty that a suspected drug caused the event."

Reports by month, five years

FDA releases FAERS data quarterly, so the newest months are incomplete and grow in later releases.

Drugs listed as suspect products in these reports

Drug	Class	Reports with this term	Share of the drug's own reports
Humira	—	1,960	0.3%
Bevacizumab	Vascular endothelial growth factor inhibitor	360	0.7%
Skyrizi	Interleukin-23 antagonist	339	0.4%
Remicade	Tumor necrosis factor blocker	328	0.2%
Vedolizumab	Integrin receptor antagonist	327	0.6%
Carboplatin	Platinum-based drug	304	0.3%
Accutane	Retinoid	284	2.3%
Prednisone	Corticosteroid	238	0.1%
Fluorouracil	Nucleoside metabolic inhibitor	205	0.3%
Cyclophosphamide	Alkylating drug	202	0.1%
Infliximab	Tumor necrosis factor blocker	193	0.4%
Capecitabine	Nucleoside metabolic inhibitor	186	0.4%
Oxaliplatin	Platinum-based drug	183	0.3%
Methotrexate	Folate analog metabolic inhibitor	171	0.1%
Revlimid	Thalidomide analog	171	0%
Clozapine	Atypical antipsychotic	163	0.2%
Paclitaxel	Microtubule inhibitor	161	0.2%
Rituximab	CD20-directed cytolytic antibody	159	0.1%
Doxorubicin	Anthracycline topoisomerase inhibitor	145	0.3%
Vincristine	—	140	0.2%
Avastin	Vascular endothelial growth factor inhibitor	134	0.2%
Benicar	Angiotensin 2 receptor blocker	132	1.6%
Cisplatin	Platinum-based drug	131	0.2%
Ozempic	GLP-1 receptor agonist	131	0.2%
Etoposide	Topoisomerase inhibitor	128	0.2%

Drugs with a page on this site, ordered by the number of their reports recording this term. The last column is the term's share within that drug's own reports, against 0.1% across the whole database. FDA states that adverse event reports "represent a small percentage of total usage numbers of a product", that "common products may have a higher number of adverse events due to the higher total number of people using the product", and that the data "by themselves are not an indicator of the safety profile of the drug or biologic."

By pharmacologic class

Class	Reports with this term	Share of class reports	Median drug in class
Tumor necrosis factor blocker	893	0.1%	0.1%
Nucleoside metabolic inhibitor	688	0.2%	0%
Platinum-based drug	618	0.3%	0.3%
Corticosteroid	546	0.1%	0%
Vascular endothelial growth factor inhibitor	504	0.3%	0%
GLP-1 receptor agonist	470	0.1%	0.1%
Integrin receptor antagonist	470	0.2%	0.2%
Kinase inhibitor	405	0%	0%
Interleukin-23 antagonist	345	0.3%	0%
Atypical antipsychotic	339	0%	0%

Classes ordered by count. Class shares follow the class's overall report volume as much as anything else.

Patients in these reports

Patient age

Under 20.2%24

2 to 110.8%93

12 to 171.6%188

18 to 4414.2%1,720

45 to 6425.8%3,118

65 to 7414.5%1,756

75 and over9.7%1,175

Age not given33.2%4,009

Patient sex

Female51.4%6,205

Male40.6%4,904

Not given8.1%974

Grey bar: all 20,646,523 reports in the database. 69.8% of these reports give the United States as the country.

Questions about "Small intestinal obstruction"

What does "Small intestinal obstruction" mean in an adverse event report?

It is a MedDRA preferred term, the dictionary FDA uses to code what a reporter described. The report's own description is not published by openFDA and is not shown here.

How many reports record small intestinal obstruction?

12,083 reports through June 2026 (0.1% of all reports), 814 of them in the latest 12 months.

Which drugs appear most often in these reports?

Humira (1,960), Bevacizumab (360), Skyrizi (339), Remicade (328) and Vedolizumab (327). Drugs with many reports overall lead almost every term's list. FDA states that adverse event reports "represent a small percentage of total usage numbers of a product", that "common products may have a higher number of adverse events due to the higher total number of people using the product", and that the data "by themselves are not an indicator of the safety profile of the drug or biologic."

Does a drug appearing here mean it was responsible for this reaction?

No. FDA states that "a causal relationship cannot be established between product and reactions listed in a report" and that for any given report "there is no certainty that a suspected drug caused the event."

I have this symptom. What should I do?

This site cannot assess anyone. A pharmacist or clinician can; for an emergency, call the local emergency number. Nothing on this page is medical advice.

Where this comes from. Counts are built from the openFDA Drug Adverse Event (FAERS) bulk export released 28 Sep 2026, which holds reports FDA received through 30 Jun 2026. Drug names are as reported, resolved to the brand or generic name on the FDA label where openFDA's harmonisation matched them; classes are the pharmacologic class (EPC) from the label and the National Drug Code Directory of 17 Sep 2026. Terms are pooled across spelling and capitalisation variants of one MedDRA preferred term. No report narrative, lot number, patient detail or reporter identity is published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.

Drug data (FAERS) through 30 Jun 2026; device data (MAUDE) through 31 Aug 2026. Not medical advice.