Vitamin c adverse event reports that FDA received

Name: Reaction terms in FDA adverse event reports that name Vitamin c
Creator: Reported Reactions
License: https://creativecommons.org/publicdomain/zero/1.0/

Name type: Generic name
Class: Vitamin C
Also reported as: Vitamin C /00008001/, Vitamin C /00266801/, Vitamin C Er

What a report is

A report is not proof that the drug was the cause of the event.

FDA says:

Adverse event reports submitted to FDA do not undergo extensive validation or verification. Therefore, a causal relationship cannot be established between product and reactions listed in a report. While a suspected relationship may exist, it is not medically validated and should not be the sole source of information for clinical decision making or other assumptions about the safety or efficacy of a product. Additionally, it is important to remember that adverse event reports represent a small percentage of total usage numbers of a product. Common products may have a higher number of adverse events due to the higher total number of people using the product.
Source: openFDA, Drug Adverse Event Overview, section "Responsible use of the data". The site read the page on 2 Oct 2026. The data have the reports that FDA received through 30 Jun 2026.

FDA also says:

There is no certainty that the reported event (adverse event or medication error) was actually due to the product. FDA does not require that a causal relationship between a product and event be proven, and reports do not always contain enough detail to properly evaluate an event. The information in these reports has not been scientifically or otherwise verified as to a cause and effect relationship and cannot be used to estimate the incidence of these events.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated.
Source: openFDA, Response of the drug event API (meta.disclaimer). The site read the page on 2 Oct 2026.

Not medical advice. This site counts what was reported to FDA. Questions about a medicine or device belong with a pharmacist or clinician.

Drug reports received through 30 Jun 2026. Device reports have a separate cutoff, 30 Sep 2026. Why a report count is not a rate.

Reports on file

From November 2004 to June 2026, FDA received 5,714 adverse event reports that name Vitamin c. In these reports the drug is a suspect or interacting product.

In the same period, 87,780 further reports name it only as a concomitant medicine. The counts on this page do not include these reports.

FDA received 1,031 reports in the 12 months to June 2026 and 1,341 in the 12 months before. FDA releases FAERS data every quarter, so the newest months are not complete. They grow in later releases.

Of the 1,332,454 drug reports that FDA received in the 12 months to June 2026, 1,031 (0.1%) name Vitamin c. Reports from other health professionals were 73.9% of the reports that name Vitamin c and 19.7% of all drug reports.

The number of people who use the product is not in the data. A count is not a rate. A count of reports is not a count of events or of patients, because one event can have more than one report.

There are many instances of duplicative reports and some reports do not contain all the necessary information.
Source: FDA, FDA Adverse Event Monitoring System (AEMS) Public Dashboard. Content current as of 11 Mar 2026. The site read the page on 2 Oct 2026.

Suspect product

FDA records each drug in a report as suspect, concomitant or interacting. This page counts the reports in which Vitamin c is suspect or interacting. FDA says:

Any number of the drugs may be marked as suspect if thought to be responsible for one or more of the reactions, but that information is not validated.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

Data version

openFDA FAERS release of 29 Oct 2026. Reports received through 30 Jun 2026.

Since the last update

FDA says:

Many factors can influence whether or not an event will be reported, such as the time a product has been marketed and publicity about an event.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

The information in these reports cannot be used to estimate the incidence (occurrence rates) of the events reported.
Source: FDA, FDA Adverse Event Monitoring System (AEMS) Public Dashboard. Content current as of 11 Mar 2026. The site read the page on 2 Oct 2026.

The latest update of the FDA data, recorded on 28 Oct 2026, changed no count of this page.

In April to June 2026, FDA received 216 reports that name Vitamin c.
In January to March 2026, FDA received 160.
In April to June 2025, FDA received 254.

April to June 2026 is the latest closed quarter in the data. A closed quarter is a quarter for which the FDA files have most of the reports.

All updates Feed of updates (RSS)

Reaction lookup

These are the reaction terms that the reports record, with the number of reports for each term. Type a term or a plain word to find its count.

What this list leaves out

The table lists the 584 reaction terms that 5 or more reports record. A term with fewer than 5 reports is not in the table.

The site keeps reaction terms for 5,673 of the 5,714 reports (99.3%).

The reports of the other years are not in the counts.

So a count in the table can be lower than the count of FDA.

Find a reaction term

The table shows the first 50 of 584 terms.

Reaction terms in the reports that name Vitamin c, most reports first
Reaction term (MedDRA) and plain meaning	Reports	Share of the 5,714 reports
Off label useused for a purpose or in a way not on the label	2,319	40.6%
Drug ineffectivethe medicine did not work as expected	1,867	32.7%
Painpain, site not specified	1,820	31.9%
Rheumatoid arthritisrheumatoid arthritis, an inflammatory joint disease	1,773	31%
Hypertensionhigh blood pressure	1,683	29.5%
Infusion related reactiona reaction during or soon after an infusion	1,666	29.2%
Rashskin rash	1,648	28.8%
Fatiguetiredness	1,642	28.7%
Headachehead pain	1,596	27.9%
Joint swellinga swollen joint	1,582	27.7%
Hepatic enzyme increasedraised liver enzymes	1,521	26.6%
Psoriatic arthropathy	1,445	25.3%
Systemic lupus erythematosuslupus, an autoimmune disease	1,430	25%
Contraindicated product administered	1,408	24.6%
Drug intolerancethe medicine was not tolerated	1,407	24.6%
Glossodynia	1,379	24.1%
Swelling	1,376	24.1%
Pemphigus	1,371	24%
Fibromyalgia	1,353	23.7%
Wound	1,343	23.5%
Drug hypersensitivityan allergic-type reaction (the term names a medicine)	1,341	23.5%
Synovitis	1,317	23%
Hypersensitivityan allergic-type reaction	1,313	23%
Vomitingbeing sick	1,310	22.9%
Abdominal discomfortstomach discomfort	1,308	22.9%
General physical health deteriorationgeneral decline in health	1,287	22.5%
Pericarditisinflammation of the sac around the heart	1,284	22.5%
Nauseafeeling sick	1,262	22.1%
Type 2 diabetes mellitustype 2 diabetes	1,262	22.1%
Arthropathy	1,246	21.8%
Maternal exposure during pregnancythe mother took the medicine during pregnancy	1,240	21.7%
Product use issuea problem in how the product was used	1,233	21.6%
Hand deformity	1,230	21.5%
Alopeciahair loss	1,216	21.3%
Pyrexiafever	1,202	21%
Weight increasedweight gain	1,197	20.9%
Wheezing	1,197	20.9%
Duodenal ulcer perforation	1,188	20.8%
Helicobacter infection	1,181	20.7%
Blood cholesterol increasedraised cholesterol	1,180	20.7%
Treatment failurethe treatment did not work	1,166	20.4%
Arthralgiajoint pain	1,160	20.3%
Hypoaesthesianumbness	1,156	20.2%
Liver injury	1,151	20.1%
Stomatitissore mouth	1,148	20.1%
Condition aggravatedthe condition being treated got worse	1,147	20.1%
Urticariahives	1,132	19.8%
Impaired healingslow healing	1,128	19.7%
Rheumatic fever	1,128	19.7%
Product use in unapproved indicationused for a purpose not on the label	1,126	19.7%

Download all 584 terms of Vitamin c (CSV)

The counts add to more than 5,714 reports, because one report can record more than one term. FDA says:

No individual drug is connected to any individual reaction. When a report lists multiple drugs and multiple reactions, there is no way to conclude from the data therein that a given drug is responsible for a given reaction.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

The CSV file has the same rows and the same limits. Its last row is a note that says so.

MedDRA term

The person who codes a report selects the preferred term that agrees best with the description of the reporter. The words under a term are the plain meaning that this site gives.

Not the label

The FDA-approved label of a product lists its adverse reactions. See the official pages at the end of this page.

Outcomes by year

The table gives the outcomes that the reporters gave, in the terms of FDA.

Outcomes in the reports that name Vitamin c, by the year of the openFDA file that holds the report

The table continues to the right.

Year of the openFDA file	Reports	Serious	Death	Life-threatening	Hospitalization (initial or prolonged)	Disability or Permanent Damage	Congenital Anomaly/Birth Defect	Other Serious (Important Medical Events)	Not serious
2004	2	2	0	0	2	0	0	0	0
2005	5	5	2	0	3	0	0	2	0
2006	1	1	0	0	0	0	0	1	0
2007	1	1	1	0	0	0	0	0	0
2008	3	2	0	0	1	0	0	1	1
2009	5	5	1	0	4	0	0	0	0
2010	4	4	0	0	2	0	0	2	0
2011	4	3	0	0	0	0	0	3	1
2012	8	7	1	1	4	0	0	5	1
2013	34	27	2	2	7	3	0	17	7
2014	29	21	2	1	7	1	0	17	8
2015	47	33	1	2	9	2	1	26	14
2016	103	87	6	4	29	7	0	70	16
2017	61	46	19	2	13	1	0	24	15
2018	70	55	0	5	30	2	0	47	15
2019	125	111	4	4	63	2	5	88	14
2020	160	140	5	8	66	4	1	110	20
2021	378	315	15	24	157	16	0	262	63
2022	489	451	59	89	262	89	0	373	38
2023	646	617	196	235	335	239	31	593	29
2024	1,101	1,084	656	674	722	658	216	1,050	17
2025	1,554	1,537	1,071	1,109	1,133	1,092	640	1,418	17
2026	884	880	659	658	673	636	412	834	4

An outcome in a report is not proof that the drug was the cause. The reporter gives the outcome, and FDA does not verify it. FDA says:

The information in these reports has not been scientifically or otherwise verified as to a cause and effect relationship and cannot be used to estimate the incidence of these events.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

The six headings with the names of FDA are the outcome terms of FDA. A report can have more than one outcome. The columns Serious and Not serious are the two values of the openFDA field serious. For the value serious, openFDA gives this description:

The adverse event resulted in death, a life threatening condition, hospitalization, disability, congenital anomaly, or other serious condition
Source: openFDA, Drug adverse event fields (YAML reference). The site read the page on 2 Oct 2026.

The year is the year of the openFDA file that holds the latest version of the report. It is not always the year in which FDA first received the report. The chart of the next section uses the year of first receipt. The latest year is not complete.

Reports by year and month

Reports that name Vitamin c, by the year in which FDA received them

The column of 2026 has an outline, because the year is not complete. It has the reports that FDA received through June 2026 only.

Show the figures of the chart as a table

Reports that name Vitamin c, by the year in which FDA received them
Year	Reports
2004	2
2005	4
2006	2
2007	1
2008	2
2009	4
2010	6
2011	4
2012	11
2013	35
2014	44
2015	61
2016	114
2017	73
2018	92
2019	192
2020	222
2021	526
2022	565
2023	777
2024	1,303
2025	1,298
2026	376

Reports that name Vitamin c, by month, five years to June 2026

FDA releases FAERS data every quarter, so the newest months are not complete. They grow in later releases.

Why a count moves

A count moves for many reasons. The guide gives FDA's words about them.

Patients and reporters

Age of the patient in the reports that name Vitamin c
Age	Reports	Share
Under 2	8	0.1%
2 to 11	91	1.6%
12 to 17	23	0.4%
18 to 44	2,185	38.2%
45 to 64	1,074	18.8%
65 to 74	204	3.6%
75 and over	445	7.8%
Age not given	1,684	29.5%

Sex of the patient in the reports that name Vitamin c
Sex	Reports	Share
Female	4,065	71.1%
Male	758	13.3%
Unknown or not given	891	15.6%

Type of reporter in the reports that name Vitamin c
Reporter	Reports	Share
Physician	685	12%
Pharmacist	75	1.3%
Other health professional	4,221	73.9%
Lawyer	2	under 0.1%
Consumer or non-health professional	692	12.1%
Not given	39	0.7%

Age and sex are as the report gives them. The reporter is the primary source in the report. 10% of the reports give the United States as the country.

Reason for use

Reason for use (indication) that the reports of Vitamin c record
Indication as recorded (MedDRA)	Reports	Share
Rheumatoid arthritis	190	3.3%
Covid-19	144	2.5%
Constipation	107	1.9%
Foetal exposure during pregnancy	82	1.4%
Vitamin supplementation	60	1.1%
Complex regional pain syndrome	50	0.9%

The reporter fills in the indication, and the field is often empty. Each share is of all 5,714 reports.

Drugs in the same reports

Other drugs that the reports of Vitamin c name, in any role, in order of name
Drug	Reports that name the two
Acetaminophen	2,981
Actemra	2,860
Diclofenac sodium	2,911
Ergocalciferol	2,820
Folic acid	2,988
Humira	2,771
Orencia	2,999
Prednisone	3,433
Rituximab	3,276
Sulfasalazine	2,853

The table has the 10 drug names that these reports name most. Two names in one report says only that the report recorded the two. It says nothing about the part of a product in the event.

FDA says:

Additionally, it is important to remember that adverse event reports represent a small percentage of total usage numbers of a product. Common products may have a higher number of adverse events due to the higher total number of people using the product.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

Importantly, the AEMS data by themselves are not an indicator of the safety profile of the drug or biologic.
Source: FDA, FDA Adverse Event Monitoring System (AEMS) Public Dashboard. Content current as of 11 Mar 2026. The site read the page on 2 Oct 2026.

Pages near this one

Multivitamin same class
Vitamin e same class
Ascorbic acid same class
Vitamin B6 next in the A to Z list
Vitamin d next in the A to Z list
Vitamin B12 next in the A to Z list
Vitamin B1 next in the A to Z list
Vitamin K1 next in the A to Z list
Vitamin B Complex next in the A to Z list
Vitamins next in the A to Z list
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Vitrakvi next in the A to Z list

These links are for navigation. No count selected them. The class page lists each drug of the class.

Official pages

DailyMed labels for Vitamin cThe labels (prescribing information) that have this name, at the National Library of Medicine.
MedWatch Online Voluntary Reporting FormThe online form of FDA for a voluntary report.
MedWatch: The FDA Safety Information and Adverse Event Reporting ProgramThe page of the FDA program that receives reports about drugs and devices.
FDA Adverse Event Monitoring System (AEMS) Public DashboardThe public dashboard of FDA for adverse event reports on drugs and biologics.

The site checked these addresses on 2 Oct 2026. The links open in a new tab.

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Reported Reactions. Vitamin c: adverse event reports that FDA received. https://reportedreactions.com/drug/vitamin-c/ Source: U.S. Food and Drug Administration, openFDA Drug Adverse Event (FAERS) files, release of 29 Oct 2026. Reports received through 30 Jun 2026.

Where the data come from

The counts come from the openFDA Drug Adverse Event (FAERS) bulk files, release of 29 Oct 2026. The files have the reports that FDA received through 30 Jun 2026. A drug name is the name on the report. The site matches it to a brand name or a generic name of the National Drug Code Directory of 2 Nov 2026. A class is the pharmacologic class (EPC) of the FDA label.

A report is in the count when it names Vitamin c as a suspect or interacting product. The 87,780 reports that name it only as a concomitant medicine are not in the count. The site does not publish a report narrative, a lot number, a detail of a patient or the identity of a reporter. The record of FDA is the authority. See how the site counts reports, the data sources and the corrections page.

Questions

Do these reports show that Vitamin c was responsible for the reactions?

No. FDA says:

For any given report, there is no certainty that a suspected drug caused the event.
Source: FDA, FDA Adverse Event Monitoring System (AEMS) Public Dashboard. Content current as of 11 Mar 2026. The site read the page on 2 Oct 2026.

A reaction can relate to the condition that the drug treats, to other medicines, or to something else.

Is this the list of reactions on the label of Vitamin c?

No. It is a count of what people reported to FDA: 5,714 reports from November 2004 to June 2026. The FDA-approved label of a product lists its adverse reactions. The official pages at the end of this page link to the labels.

Who sent these reports?

Other health professional (73.9%), consumer or non-health professional (12.1%) and physician (12%). These are the types of reporter for the reports that name this drug.

If a manufacturer receives an adverse event report, it is normally required to send the report to FDA.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

How does a person report an adverse event?

FDA runs MedWatch, a program that takes voluntary reports from health professionals, patients and consumers. The guide on how to report has the links.

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