Cardiac murmur adverse event reports that record this term

Kind of term: MedDRA preferred term

What a report is

A report is not proof that the drug was the cause of the event.

FDA says:

Adverse event reports submitted to FDA do not undergo extensive validation or verification. Therefore, a causal relationship cannot be established between product and reactions listed in a report. While a suspected relationship may exist, it is not medically validated and should not be the sole source of information for clinical decision making or other assumptions about the safety or efficacy of a product. Additionally, it is important to remember that adverse event reports represent a small percentage of total usage numbers of a product. Common products may have a higher number of adverse events due to the higher total number of people using the product.
Source: openFDA, Drug Adverse Event Overview, section "Responsible use of the data". The site read the page on 2 Oct 2026. The data have the reports that FDA received through 30 Jun 2026.

FDA also says:

There is no certainty that the reported event (adverse event or medication error) was actually due to the product. FDA does not require that a causal relationship between a product and event be proven, and reports do not always contain enough detail to properly evaluate an event. The information in these reports has not been scientifically or otherwise verified as to a cause and effect relationship and cannot be used to estimate the incidence of these events.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated.
Source: openFDA, Response of the drug event API (meta.disclaimer). The site read the page on 2 Oct 2026.

Not medical advice. This site counts what was reported to FDA. Questions about a medicine or device belong with a pharmacist or clinician.

Reports on file

From January 2004 to June 2026, FDA received 8,477 adverse event reports that record the MedDRA preferred term Cardiac murmur. The person who codes a report selects the term that agrees best with the description of the reporter.

FDA received 252 reports in the 12 months to June 2026 and 308 in the 12 months before. FDA releases FAERS data every quarter, so the newest months are not complete. They grow in later releases.

By reports in the 12 months to June 2026, this term was number 1,281 of 1,436 reaction terms with a page. Of the 1,332,454 drug reports that FDA received in the 12 months to June 2026, 252 (under 0.1%) record this term. Reports for patients under 2 were 5.5% of the reports that record this term and 0.5% of all drug reports.

The number of people who use the product is not in the data. A count is not a rate.

MedDRA

The Medical Dictionary for Regulatory Activities. The person who codes a report selects the preferred term that agrees best with the description of the reporter. FDA does not publish the description.

Data version

openFDA FAERS release of 29 Oct 2026. Reports received through 30 Jun 2026.

Drugs in these reports

The table has the 127 drug pages with 50 or more reports that record this term. The rows are in order of name. A drug page with fewer reports for this term is not in the table. The counts are the counts that the site keeps for each reaction term, and a count can be lower than the count of FDA.

FDA says:

Additionally, it is important to remember that adverse event reports represent a small percentage of total usage numbers of a product. Common products may have a higher number of adverse events due to the higher total number of people using the product.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

Importantly, the AEMS data by themselves are not an indicator of the safety profile of the drug or biologic.
Source: FDA, FDA Adverse Event Monitoring System (AEMS) Public Dashboard. Content current as of 11 Mar 2026. The site read the page on 2 Oct 2026.

Drugs that the reports with the term Cardiac murmur name as a suspect product, in order of name
Drug	Class	Reports with this term
Acetaminophen		272
Aclidinium bromide	Anticholinergic	136
Aclidinium Bromide Formoterol Fumarate		120
Actemra	Interleukin-6 receptor antagonist	71
Adalimumab	Tumor necrosis factor blocker	149
Advair Hfa	Corticosteroid	58
Albendazole		116
Albuterol	beta2-Adrenergic agonist	141
Albuterol sulfate	beta2-Adrenergic agonist	111
Alendronate sodium	Bisphosphonate	191
Anoro Ellipta	Anticholinergic	53
Aptivus		85
Aredia		67
Asacol		141
Aspirin	Nonsteroidal anti-inflammatory drug	224
Atorvastatin		69
Avandia		86
Azithromycin	Macrolide antimicrobial	120
Azithromycin Anhydrous		53
Bisoprolol	beta-Adrenergic blocker	90
Breo Ellipta	Corticosteroid	170
Budesonide	Corticosteroid	225
Budesonide Formoterol Fumarate		130
Candesartan	Angiotensin 2 receptor blocker	139
Cholecalciferol		136
Ciprofloxacin	Fluoroquinolone antibacterial	52
Ciprofloxacin hydrochloride	Fluoroquinolone antibacterial	116
Clonazepam	Benzodiazepine	117
Combivent		58
Combivir	Hepatitis B virus nucleoside analog reverse transcriptase inhibitor	52
Comirnaty		107
Cortifoam	Corticosteroid	133
Cortisone	Corticosteroid	77
Crestor	HMG-CoA reductase inhibitor	65
Dapagliflozin	Sodium-Glucose cotransporter 2 inhibitor	142
Desoximetasone	Corticosteroid	92
Diazepam	Benzodiazepine	130
Digoxin	Cardiac glycoside	352
Divalproex sodium	Anti-epileptic agent	88
Enbrel	Tumor necrosis factor blocker	145
Entresto	Angiotensin 2 receptor blocker	68
Entyvio	Integrin receptor antagonist	145
Epinephrine	Catecholamine	84
Epinephrine hydrochloride	Catecholamine	68
Ergocalciferol	Provitamin D2 compound	92
Escitalopram	Serotonin reuptake inhibitor	135
Esomeprazole	Proton pump inhibitor	132
Felodipine	Dihydropyridine calcium channel blocker	154
Fosamax	Bisphosphonate	434
Fosamax Plus D		80
Furosemide	Loop diuretic	282
Gabapentin	Anti-epileptic agent	159
Glycopyrrolate	Anticholinergic	133
Glycopyrronium Indacaterol		108
Humira		427
Hydrocortisone	Corticosteroid	141
Hydrocortisone acetate	Corticosteroid	59
Inflectra	Tumor necrosis factor blocker	59
Infliximab	Tumor necrosis factor blocker	155
Ipratropium bromide	Anticholinergic	199
Kaletra	Cytochrome P450 3A inhibitor	58
Lamotrigine	Anti-epileptic agent	56
Lansoprazole	Proton pump inhibitor	54
Levothyroxine		91
Levothyroxine sodium	l-Thyroxine	106
Lisdexamfetamine dimesylate	Central nervous system stimulant	94
Lisinopril	Angiotensin converting enzyme inhibitor	61
Mebeverine		62
Mepolizumab	Interleukin-5 antagonist	152
Mesalamine	Aminosalicylate	160
Metformin	Biguanide	179
Methotrexate	Folate analog metabolic inhibitor	91
Moxifloxacin	Fluoroquinolone antibacterial	65
Moxifloxacin hydrochloride	Fluoroquinolone antibacterial	98
Nasonex	Corticosteroid	158
Nucala	Interleukin-5 antagonist	92
Olanzapine	Atypical antipsychotic	102
Olodaterol Hydrochloride Tiotropium Bromide Monohydrate		113
Omeprazole	Proton pump inhibitor	161
Omnaris		152
Ondansetron	Serotonin-3 receptor antagonist	103
Oxycodone	Opioid agonist	113
Oxycodone hydrochloride	Opioid agonist	69
Pantoprazole	Proton pump inhibitor	77
Para-Aminosalicylic Acid		94
Paroxetine hydrochloride	Serotonin reuptake inhibitor	86
Paxil	Serotonin reuptake inhibitor	741
Perindopril		50
Prednisone	Corticosteroid	411
Procyclidine hydrochloride		91
Prozac	Serotonin reuptake inhibitor	101
Quetiapine	Atypical antipsychotic	71
Quetiapine fumarate	Atypical antipsychotic	72
Ramipril	Angiotensin converting enzyme inhibitor	53
Remicade	Tumor necrosis factor blocker	82
Revlimid	Thalidomide analog	59
Risperidone	Atypical antipsychotic	114
Rituximab	CD20-directed cytolytic antibody	62
Rivaroxaban	Factor Xa inhibitor	61
Rosuvastatin	HMG-CoA reductase inhibitor	119
Seroquel	Atypical antipsychotic	60
Singulair	Leukotriene receptor antagonist	180
Sulfasalazine	Aminosalicylate	156
Symbicort	Corticosteroid	87
Tegretol	Mood stabilizer	110
Tiotropium bromide	Anticholinergic	181
Tiotropium bromide monohydrate		96
Tipranavir		89
Tozinameran		74
Trazodone		139
Truvada	Human immunodeficiency virus nucleoside analog reverse transcriptase inhibitor	51
Umeclidinium bromide		125
Umeclidinium Bromide Vilanterol Trifenatate		82
Valproate sodium	Anti-epileptic agent	66
Vedolizumab	Integrin receptor antagonist	102
Vioxx		289
Vyvanse	Central nervous system stimulant	69
Warfarin	Vitamin K antagonist	138
Warfarin sodium	Vitamin K antagonist	118
Xarelto	Factor Xa inhibitor	60
Xyrem	Central nervous system depressant	63
Zenhale		163
Zofran		301
Zofran Odt		87
Zoloft	Serotonin reuptake inhibitor	63
Zometa		99
Zyprexa	Atypical antipsychotic	93

The page of each drug has the count of each reaction term in its reaction lookup.

Drug classes in these reports

The table has the 55 pharmacologic classes with 50 or more reports that record this term. The rows are in order of name.

FDA says:

Additionally, it is important to remember that adverse event reports represent a small percentage of total usage numbers of a product. Common products may have a higher number of adverse events due to the higher total number of people using the product.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

Importantly, the AEMS data by themselves are not an indicator of the safety profile of the drug or biologic.
Source: FDA, FDA Adverse Event Monitoring System (AEMS) Public Dashboard. Content current as of 11 Mar 2026. The site read the page on 2 Oct 2026.

Pharmacologic classes of the drugs that the reports with the term Cardiac murmur name, in order of name
Class	Reports with this term
Aldosterone antagonist	70
Aminosalicylate	320
Angiotensin 2 receptor blocker	319
Angiotensin converting enzyme inhibitor	151
Anti-epileptic agent	429
Anti-IgE	87
Anticholinergic	738
Antimalarial	53
Atypical antipsychotic	604
Benzodiazepine	267
beta-Adrenergic blocker	168
beta2-Adrenergic agonist	265
Biguanide	222
Bisphosphonate	658
Calcineurin inhibitor immunosuppressant	53
Calcium channel blocker	53
Cardiac glycoside	354
Catecholamine	88
CD20-directed cytolytic antibody	109
Central nervous system depressant	72
Central nervous system stimulant	193
Corticosteroid	1,667
Cytochrome P450 3A inhibitor	120
Dihydropyridine calcium channel blocker	166
Endothelin receptor antagonist	70
Factor Xa inhibitor	152
Fluoroquinolone antibacterial	333
Folate analog metabolic inhibitor	105
Hepatitis B virus nucleoside analog reverse transcriptase inhibitor	103
HMG-CoA reductase inhibitor	290
Human immunodeficiency virus integrase strand transfer inhibitor	54
Human immunodeficiency virus nucleoside analog reverse transcriptase inhibitor	138
Integrin receptor antagonist	276
Interleukin-5 antagonist	244
Interleukin-6 receptor antagonist	71
Janus kinase inhibitor	64
Kinase inhibitor	139
l-Thyroxine	112
Leukotriene receptor antagonist	248
Loop diuretic	317
Macrolide antimicrobial	132
Mood stabilizer	153
Nitrofuran antibacterial	60
Nonsteroidal anti-inflammatory drug	335
Opioid agonist	314
Protease inhibitor	75
Proton pump inhibitor	526
Provitamin D2 compound	95
Serotonin reuptake inhibitor	1,265
Serotonin-3 receptor antagonist	146
Sodium-Glucose cotransporter 2 inhibitor	152
Thalidomide analog	63
Thiazide-like diuretic	50
Tumor necrosis factor blocker	612
Vitamin K antagonist	256

A class with many reports in all has many reports for almost every term.

Reports by month

Reports that record Cardiac murmur, by month, five years to June 2026

FDA releases FAERS data every quarter, so the newest months are not complete. They grow in later releases.

Patients in these reports

Age of the patient in the reports that record Cardiac murmur
Age	Reports	Share
Under 2	468	5.5%
2 to 11	143	1.7%
12 to 17	97	1.1%
18 to 44	689	8.1%
45 to 64	1,551	18.3%
65 to 74	880	10.4%
75 and over	959	11.3%
Age not given	3,690	43.5%

Sex of the patient in the reports that record Cardiac murmur
Sex	Reports	Share
Female	4,758	56.1%
Male	3,040	35.9%
Unknown or not given	679	8%

Age and sex are as the report gives them. 63.5% of these reports give the United States as the country.

Terms near this one

These are the next terms in the A to Z list. The links are for navigation.

Official pages

MedWatch Online Voluntary Reporting FormThe online form of FDA for a voluntary report.
MedWatch: The FDA Safety Information and Adverse Event Reporting ProgramThe page of the FDA program that receives reports about drugs and devices.
FDA Adverse Event Monitoring System (AEMS) Public DashboardThe public dashboard of FDA for adverse event reports on drugs and biologics.

The site checked these addresses on 2 Oct 2026. The links open in a new tab.

Cite this page

Reported Reactions. Cardiac murmur: adverse event reports that record this term. https://reportedreactions.com/reaction/cardiac-murmur/ Source: U.S. Food and Drug Administration, openFDA Drug Adverse Event (FAERS) files, release of 29 Oct 2026. Reports received through 30 Jun 2026.

Where the data come from

The counts come from the openFDA Drug Adverse Event (FAERS) bulk files, release of 29 Oct 2026. The files have the reports that FDA received through 30 Jun 2026. A drug name is the name on the report. The site matches it to a brand name or a generic name of the National Drug Code Directory of 2 Nov 2026. A class is the pharmacologic class (EPC) of the FDA label.

The count has the reports with each spelling of one MedDRA preferred term. The site does not publish a report narrative, a lot number, a detail of a patient or the identity of a reporter. The record of FDA is the authority. See how the site counts reports, the data sources and the corrections page.

Questions

What does Cardiac murmur mean in an adverse event report?

It is a MedDRA preferred term. FDA codes the description of a reporter with the MedDRA dictionary. The openFDA files do not have the description itself, and this site does not show it.

Does a drug in the table mean that the drug was responsible for this reaction?

No. FDA says:

No individual drug is connected to any individual reaction.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

When a report lists multiple drugs and multiple reactions, there is no way to conclude from the data therein that a given drug is responsible for a given reaction.
Source: openFDA, Drug Adverse Event Overview. The site read the page on 2 Oct 2026.

What does this page tell a person who has this symptom?

This page gives counts of reports. It cannot assess a person. A pharmacist or a clinician can assess a person.

If this is a medical emergency, please call 911.
Source: FDA, MedWatch Online Voluntary Reporting Form. The site read the page on 2 Oct 2026.

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