MedDRA preferred term

Blood lactic acid increased: adverse event reports recording this term

5,051 reports to FDA record it, 2004–2026; 0% of the database.

Read first · FDA's statement on these data

Adverse event reports submitted to FDA do not undergo extensive validation or verification. Therefore, a causal relationship cannot be established between product and reactions listed in a report. While a suspected relationship may exist, it is not medically validated and should not be the sole source of information for clinical decision making or other assumptions about the safety or efficacy of a product. Additionally, it is important to remember that adverse event reports represent a small percentage of total usage numbers of a product. Common products may have a higher number of adverse events due to the higher total number of people using the product. openFDA, FDA

FDA adds: "There is no certainty that the reported event (adverse event or medication error) was actually due to the product. FDA does not require that a causal relationship between a product and event be proven, and reports do not always contain enough detail to properly evaluate an event." The information in these reports "cannot be used to estimate the incidence of these events."

Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated.

Not medical advice. This site counts what was reported to FDA. Questions about a medicine or device belong with a pharmacist or clinician.

5,051
reports recording the term: 0% of all reports; 361
reports, 12 months to June 2026: 402 in the 12 months before; 97.2%
marked serious by the reporter: 57.4% across all reports; 19%
record death among outcomes, as reported: 9.1% across all reports

5,051 reports in FDA's adverse event database record the MedDRA term "Blood lactic acid increased": 0% of all reports received between January 2004 and June 2026. Coders pick the term that best matches the reporter's description.

361 reports recorded it in the 12 months to June 2026, down 10% from 402 in the 12 months before. FDA releases FAERS data quarterly, so the newest months are incomplete and grow in later releases. Of reports recording this term, 97.2% are marked serious, 19% include death among the outcomes and 77.2% include hospitalisation, as reported.

The drugs listed most often as suspect products in those reports are Metformin, Prednisone and Albuterol. That order mostly follows how many reports each drug has overall; the table also gives the term's share within each drug's own reports. FDA states that "a causal relationship cannot be established between product and reactions listed in a report" and that for any given report "there is no certainty that a suspected drug caused the event."

Reports by month, five years

FDA releases FAERS data quarterly, so the newest months are incomplete and grow in later releases.

Drugs listed as suspect products in these reports

Drug	Class	Reports with this term	Share of the drug's own reports
Metformin	Biguanide	469	0.7%
Prednisone	Corticosteroid	280	0.2%
Albuterol	beta2-Adrenergic agonist	215	1.2%
Tamiflu	Neuraminidase inhibitor	202	1.5%
Nucala	Interleukin-5 antagonist	196	0.6%
Omalizumab	Anti-IgE	196	1.9%
Amlodipine	Calcium channel blocker	195	0.4%
Singulair	Leukotriene receptor antagonist	189	1%
Pulmicort Turbuhaler	—	185	4.2%
Ceftriaxone sodium	Cephalosporin antibacterial	181	4.8%
Rupatadine Fumarate	—	177	45.7%
Rupatadine	—	169	29.3%
Acetaminophen	Nonsteroidal anti-inflammatory drug	156	0.2%
Budesonide	Corticosteroid	123	0.8%
Metformin hydrochloride	Biguanide	119	0.5%
Azithromycin	Macrolide antimicrobial	112	0.6%
Zerit	—	111	9.3%
Propofol	General anesthetic	99	0.5%
Quetiapine	Atypical antipsychotic	89	0.2%
Dexamethasone	Corticosteroid	87	0.1%
Lamivudine	Hepatitis B virus nucleoside analog reverse transcriptase inhibitor	85	0.5%
Retrovir	Human immunodeficiency virus nucleoside analog reverse transcriptase inhibitor	84	4.1%
Ibuprofen	Nonsteroidal anti-inflammatory drug	80	0.1%
Zidovudine	Human immunodeficiency virus nucleoside analog reverse transcriptase inhibitor	80	0.9%
Methotrexate	Folate analog metabolic inhibitor	77	0%

Drugs with a page on this site, ordered by the number of their reports recording this term. The last column is the term's share within that drug's own reports, against 0% across the whole database. FDA states that adverse event reports "represent a small percentage of total usage numbers of a product", that "common products may have a higher number of adverse events due to the higher total number of people using the product", and that the data "by themselves are not an indicator of the safety profile of the drug or biologic."

By pharmacologic class

Class	Reports with this term	Share of class reports	Median drug in class
Biguanide	666	0.6%	0.1%
Corticosteroid	614	0.1%	0%
Nonsteroidal anti-inflammatory drug	334	0.1%	0%
Benzodiazepine	303	0.1%	0%
Hepatitis B virus nucleoside analog reverse transcriptase inhibitor	254	0.4%	0.1%
Anti-epileptic agent	246	0.1%	0%
Atypical antipsychotic	242	0%	0%
beta2-Adrenergic agonist	242	0.3%	0%
Human immunodeficiency virus nucleoside analog reverse transcriptase inhibitor	232	0.3%	0.1%
Leukotriene receptor antagonist	228	0.6%	0.3%

Classes ordered by count. Class shares follow the class's overall report volume as much as anything else.

Patients in these reports

Patient age

Under 23.3%165

2 to 112.7%136

12 to 174.1%209

18 to 4420.6%1,040

45 to 6427.7%1,399

65 to 7412.5%630

75 and over11.4%577

Age not given17.7%895

Patient sex

Female46.6%2,353

Male43.2%2,181

Not given10.2%517

Grey bar: all 20,646,523 reports in the database. 42.6% of these reports give the United States as the country.

Questions about "Blood lactic acid increased"

What does "Blood lactic acid increased" mean in an adverse event report?

It is a MedDRA preferred term, the dictionary FDA uses to code what a reporter described. The report's own description is not published by openFDA and is not shown here.

How many reports record blood lactic acid increased?

5,051 reports through June 2026 (0% of all reports), 361 of them in the latest 12 months.

Which drugs appear most often in these reports?

Metformin (469), Prednisone (280), Albuterol (215), Tamiflu (202) and Nucala (196). Drugs with many reports overall lead almost every term's list. FDA states that adverse event reports "represent a small percentage of total usage numbers of a product", that "common products may have a higher number of adverse events due to the higher total number of people using the product", and that the data "by themselves are not an indicator of the safety profile of the drug or biologic."

Does a drug appearing here mean it was responsible for this reaction?

No. FDA states that "a causal relationship cannot be established between product and reactions listed in a report" and that for any given report "there is no certainty that a suspected drug caused the event."

I have this symptom. What should I do?

This site cannot assess anyone. A pharmacist or clinician can; for an emergency, call the local emergency number. Nothing on this page is medical advice.

Where this comes from. Counts are built from the openFDA Drug Adverse Event (FAERS) bulk export released 28 Sep 2026, which holds reports FDA received through 30 Jun 2026. Drug names are as reported, resolved to the brand or generic name on the FDA label where openFDA's harmonisation matched them; classes are the pharmacologic class (EPC) from the label and the National Drug Code Directory of 17 Sep 2026. Terms are pooled across spelling and capitalisation variants of one MedDRA preferred term. No report narrative, lot number, patient detail or reporter identity is published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.

Drug data (FAERS) through 30 Jun 2026; device data (MAUDE) through 31 Aug 2026. Not medical advice.